NeuroQuant® FAQ

  • What does NeuroQuant Provide?

    NeuroQuant automatically analyzes 3D MR images and provides accurate, consistent and repeatable segmentation and measurements of brain structure volumes, which are then compared to age- and sex-matched reference data.

  • How does NeuroQuant work?

    NeuroQuant automatic processing steps:

    1. 3D T1 MR image data uploaded to software for processing
    2. Registers the images to Dynamic Atlas™
    3. Identifies and labels anatomical brain structures
    4. Measures the volumes of brain structures
    5. Compares the brain structure volumes to a unique normative database (adjusted for age, gender, and cranial volume)
    6. Provides longitudinal tracking from prior studies
    7. Returns a new, full-volume, spatial corrected and automatically labeled image dataset, along with printable patient reports, in minutes, with no user intervention.
  • Who can use NeuroQuant?

    NeuroQuant is used by radiologists, neurologists, neuroradiologists, and researchers to obtain objective, enriching, quantitative data. This valuable data aids in their clinical treatment planning and disease progression monitoring of patients with neurological conditions, such as Alzheimer’s disease and other types of dementia, traumatic brain injury (TBI), multiple sclerosis and epilepsy, and in the evaluation of brain development.

  • Can NeuroQuant be used in clinical practice worldwide?

    Yes, NeuroQuant is FDA cleared (2006), CE marked (2014), and Australia (2014), Health Canada (2016), and Korea (2016) licensed.

  • Is NeuroQuant reimbursable?

    In the US, reimbursement is possible using CPT code 76377 for medically indicated 3D volumetric post-processing.

  • Can NeuroQuant be used with PowerScribe 360?

    Yes, NeuroQuant can now be integrated with PowerScribe® 360 to streamline dictation of NeuroQuant results.

    System requirements

    PowerScribe 360 integration works with NeuroQuant on both our cloud-based and locally installed systems.

    • An activated PowerScribe 360 subscription license from CorTechs Labs
    • A CorTechs Labs online account for LesionQuant
    • CTXNode version 2.4 or higher
    • PowerScribe 360 version 3.0 and higher
  • What is the output of the device?

    The reports are provided in PDF format encapsulated in DICOM:

    • Age Related Atrophy Report
    • Hippocampal Volume Asymmetry Report
    • Multi Structure Atrophy Report
    • Triage Brain Atrophy Report
    • Brain Development Report
    • General Morphometry Report

    Additional output includes:

    • Color-Coded Brain Segmentation: a 3D MR series with each color representing a specific segmental structure, in standard DICOM format viewable on standard PACS or other DICOM viewer
    • Longitudinal Study: A longitudinal assessment of the same patient at multiple scan intervals to examine regional atrophy over time
  • Can multiple reports be selected?

    Physicians can request multiple reports in one processing session, thus improving the overall workflow when using NeuroQuant to assess complex conditions.

  • How can a patient's previous scan be combined with a new scan into a single report?

    For patients that have been scanned previously and have existing NeuroQuant reports in PACS, simply send or upload a previous report to NeuroQuant – the multi-time-point report will then be generated and show trajectory over time for that patient when a new scan is processed. If the previous scan is still on the NeuroQuant system, there is no need to upload anything in advance – the multi-time-point report will be created automatically when a follow-up scan is processed.

    NOTE: Creating multi-time-point reports between different software versions of NeuroQuant is not possible. If the previous report was created prior to version 3.0, the source DICOM data must be sent to NeuroQuant for processing in version 3.0. Then, the current NeuroQuant sequence can be processed in order to create the multi-time-point report.

LesionQuant™ FAQ

  • What does LesionQuant Provide?

    LesionQuant automatically analyzes 3D T1 and 2D or 3D FLAIR MR images and provides accurate, consistent and repeatable segmentation and measurements of lesions from DICOM images to provide lesion segmentation, counts and volumes and change, as well as brain structure volumes, which are compared to age- and gender-matched reference data.

  • How does the LesionQuant module of NeuroQuant work?

    LesionQuant automatic processing steps:

    1. 3D T1 and 2D or 3D FLAIR MR image data uploaded to software for processing
    2. Registers the images to Dynamic Atlas™
    3. Identifies and labels anatomical brain structures
    4. Measures the volumes of lesions and brain structures
    5. Compares the brain structure volumes to a unique normative database (adjusted for age, gender and cranial volume)
    6. Counts all, new, and enlarging lesions and calculate lesion burden
    7. Provides change and longitudinal tracking from prior studies
    8. Returns a new, full-volume, spatial corrected and automatically labeled image dataset, along with printable patient reports in under 30 minutes, with no user intervention.
  • Who can use LesionQuant?

    LesionQuant is used by radiologists, neurologists, neuroradiologists, and researchers to obtain objective, valuable, enriching, quantitative data to aid in their clinical treatment planning and disease progression monitoring of patients with neurological conditions, such as multiple sclerosis.

  • Can LesionQuant be used in clinical practice worldwide?

    Yes. LesionQuant is a module of NeuroQuant, which is FDA cleared (2006), CE marked (2014), and Australia (2014), Health Canada (2016), and Korea (2016) licensed.

  • Is LesionQuant reimbursable?

    In the US, reimbursement is possible using CPT code 76377 for medically indicated 3D volumetric post-processing.

  • Can LesionQuant be used with PowerScribe 360?

    Yes, LesionQuant can now be integrated with PowerScribe® 360 to streamline dictation of LesionQuant results.

    System requirements

    PowerScribe 360 integration works with LesionQuant on both our cloud-based and locally installed systems.

    • An activated PowerScribe 360 subscription license from CorTechs Labs
    • A CorTechs Labs online account for LesionQuant
    • CTXNode version 2.4 or higher
    • PowerScribe 360 version 3.0 and higher
  • What is the output of LesionQuant?
    • FLAIR lesion segmentation overlay on top of FLAIR images in DICOM format: Lesions are color-coded based on where they are anatomically located in the brain.
    • FLAIR lesion change overlay on top of FLAIR images in DICOM format: Lesions are color-coded to distinguish between increasing and decreasing volumes (when current and prior scans are processed).
    • Report: PDF format encapsulated in DICOM
  • What does the color-coding indicate on the lesion change overlay images?

    LesionQuant identifies areas of significant changes in image intensity and color codes the region, based on whether the intensity is decreasing or increasing. For example:

    • A growing MS lesion will likely increase in FLAIR intensity and size over time, which would appear red-to-yellow/orange in the LesionQuant Change volume.
    • A lesion that is in the process of resolving will shrink and become less FLAIR bright, which will then be labeled dark blue to cyan.
  • What does the color-coding indicate on the lesion segmentation overlay images?

    In order to obtain the most lesion information possible in a quick revision of the images, LesionQuant classifies any identified lesion by a region-specific color code.

    • Leukocortical lesions are red
    • Periventricular lesions are purple
    • Infrantentorial lesions are orange
    • Lesions only touching white matter are yellow

    Colors may appear lighter or darker due to image intensities.

  • What are the different report options?
    • LesionQuant FLAIR Lesion Report PLUS
      • Total number and volume of lesions, enlarging lesions and new lesions Anatomical distribution of lesions
      • White matter lesion burden
      • Histogram of lesion volume distributions
      • Current and prior volume with normative percentiles & volume and normative percentile change for 8 brain structures with age- and gender-matched reference charts
    • LesionQuant FLAIR Lesion Report
      • Total number and volume of lesions, enlarging lesions and new lesions
      • Current volume & normative percentile change of 4 brain structures with age-and gender-matched reference charts.
  • How can a patient's prior/baseline scan be combined with a new/current scan?

    For LesionQuant to generate output, at least one pair (3D T1 and 2D or 3D FLAIR) needs to be submitted for processing.

    If two time-points are available, first send the prior/baseline series images (paired 3D T1 and 2D or 3D FLAIR), and then send the new/current series of images (paired 3D T1 and 2D or 3D FLAIR). The Patient ID must match in both the submitted series and pairs of images.

  • Can more than 2 time-points be compared? How do you handle multiple follow-ups over years?

    Similar to NeuroQuant, LesionQuant can track disease progression over time.

    For patients that have an existing LesionQuant in the system, the multi-time-point report will automatically generate and show trajectory over time when a new scan pair (sagital 3D T1 and T2 FLAIR) is processed. When the previous LesionQuant report is no longer available in the system, you will need to reprocess the first timepoint scan pair
    For lesion volumes, however, only two time-points can be viewed in a single report.

  • When comparing two scans, do both time-points need to be performed on the exact same scanner?

    We recommend performing both scans on the same scanner using the same protocol for best results. If different scanners or protocols are being used, caution should be taken when interpreting the results.

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